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A nurse is caring for a 65-year-old client who has undergone a hernia operation. The client receives morphine via patient-controlled anesthesia for postoperative pain. The client also receives sulfamethoxazole-trimethoprim every 12 hours to treat a urinary tract infection, and an iron supplement for anemia. The client is on mobility restrictions because of the opioids. The client explains that while they usually pass stool once per day, they have passed stool four times today. The health care provider has diagnosed diarrhea. What is most likely contributing to this outcome?